Melioidosis
The disease has a insidious onset, fever for more than 3 weeks, body pain and loss of appetite
Multiple abscess in the lungs, liver, kidney and soft tissue
Caused by - Burkholderia pseudomallei
Diagnosis
Mainly based on the culture of blood,urine or pus from abscess
Identification of the organism is based on the following
Grey moist colonies on blood agar with metallic sheen which has a crumbled paper appearance on 48 hrs of incubation
Gram stain reveals - safety pin appearance of the gram negative bacilli
Mac Conkey agar - non lactose fermenting colonies crumbled paper appearance
Oxidase positive
Indole negative
TSI - k/k no gas,no H2S
Citrate positive
Urease negative
Mannitol motility- fermented, motile
OF glucose Oxidatively utilised
OF mannitol "
OF lactose "
OF maltose "
Arginine de hydrolysed
Polymyxin B (300units) - resistant
Treatment
Cotrimoxazole is the drug of choice given over a period of 6 months
In severe cases carbapenems are the drug of choice
The disease has a insidious onset, fever for more than 3 weeks, body pain and loss of appetite
Multiple abscess in the lungs, liver, kidney and soft tissue
Caused by - Burkholderia pseudomallei
Diagnosis
Mainly based on the culture of blood,urine or pus from abscess
Identification of the organism is based on the following
Grey moist colonies on blood agar with metallic sheen which has a crumbled paper appearance on 48 hrs of incubation
Gram stain reveals - safety pin appearance of the gram negative bacilli
Mac Conkey agar - non lactose fermenting colonies crumbled paper appearance
Indole negative
TSI - k/k no gas,no H2S
Citrate positive
Urease negative
Mannitol motility- fermented, motile
OF glucose Oxidatively utilised
OF mannitol "
OF lactose "
OF maltose "
Arginine de hydrolysed
Polymyxin B (300units) - resistant
Treatment
Cotrimoxazole is the drug of choice given over a period of 6 months
In severe cases carbapenems are the drug of choice
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